I've been running EMET 4 on my Windows 8 workstation for a week or so now, and am starting to look at using it more broadly and utilizing GPO. The deployment part is easy, Local Update Publisher has it handled. I've added the .admx to the central store, so I have the policies available.
Is anyone using it on workstations? Did you have any problems? How are you verifying the settings work? I know taking it slow is definitely the name of the game here.