Zero-Day Malware - Who Offers the Best Endpoint Protection?

Please note this post is NOT a "Which anti-virus is best?" but is instead focused on products specializing in alternative zero-day protection techniques.

There are a number of ways to identify malware, with by far the most common being definition-based blacklists. This approach just isn't working and seemingly will only continue to worsen.

I am looking a solution that does NOT use a definition-based blacklist as the primary way to identify and prevent malware (although it might contain this functionality as a secondary feature). This is opposite from mostcontemporary anti-malware products.

I have found some interesting solutions, all of which appear to offer an alternate approach to protection and detection:

1. Comodo - http://www.comodo.com/business-enterprise/cesm3/index_v2.php
2. Cylance - http://cylance.com/products/protect/
3. Webroot - ...